Poorly ventilated system cases can shorten the life of the hard drive
Ambient air temperatures of 95°F (35°C) or greater and poor ventilation from the smaller case designs of Shuttle boxes, LAN party boxes, racks, cabinets, and drawers, can shorten the life of your hard disk.
Can I physically install my drive sideways, upside down or vertically?
All Seagate and Maxtor-brand hard drives can be fitted sideways or upside down. As long as they are not moved during use and get enough cooling, it is irrelevant in which direction they are mounted.
Seagate products are run by firmware. Having the latest firmware can improve performance and or reliability of your product.
Serial ATA and Serial Attached SCSI Overview