How do I change or disable the Control-S shortcut for 1-Click Backup? Other programs use control-S as well.

Be sure you are running the latest version of the 1-Click backup software for Mac or PC. The newer version solved a problem with other applications also using Control-S. If that doesn’t solve the issue, you may disable the shortcut by go to System Preferences-> Accounts->Login Items and remove laciebackupd. To add it again, rerun the LaCie Backup Installer.